The IA6-2 monoclonal antibody reacts with the heavy chain of human Immunoglobulin D (IgD), a type I transmembrane glycoprotein and member of the immunoglobulin superfamily. IgD is co-expressed with membrane IgM on the surface of mature naïve B cells, where both isotypes associate with the Igα/Igβ (CD79a/CD79b) signaling heterodimer to form the B cell antigen receptor (BCR) complex. Engagement of the IgD-BCR by antigen mediates signal transduction that fine-tunes B cell activation, selection, and tolerance, complementing rather than duplicating IgM-BCR signaling. IgD expression is lost following isotype class switching, and a soluble form of IgD circulates at low levels in serum, where it has also been implicated in mucosal innate immune defense through interactions with basophils and mast cells.

PRODUCT DETAILS

Clone: IA6-2

Specificity: IgD

Reactivity: Human

Format: Purified

Isotype: Mouse IgG2a, k

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: Recommended dilution: 2-4 μg/ml.

REFERENCES

1. Geisberger, R. et al. 2006. Immunology 118: 429–437.
2. Chen, K. and Cerutti, A. 2011. Curr. Opin. Immunol. 23: 345–352.
3. Gutzeit, C. et al. 2018. Eur. J. Immunol. 48: 1101–1113.

For research use only. Not intended for use in diagnostic procedures.