Purified Anti-Human CD8a (Hit8a)
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説明
The Hit8a antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
The Hit8a antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. If used together with an alternative Anti-Human CD8a clone RPA-T8, the Hit8a antibody will not block binding of RPA-T8 to CD8a.
Name | Purified Anti-Human CD8a (Hit8a) |
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Cat. No. | 70-0089 |
Alternative Names | CD8 alpha, leu-2a |
Gene ID | 925 |
Clone | Hit8a |
Isotype | Mouse IgG1, kappa |
Reactivity | Human |
Cross Reactivity | Chimpanzee, Rhesus |
Format | Purified |
Application | Flow Cytometry, IHC |