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C57Bl/6 splenocytes were stained with 0.5 ug PerCP-Cyanine5.5 Anti-Mouse CD274 (65-1243) (solid line) or 0.5 ug PerCP-Cyanine5.5 Rat IgG2b isotype control (dashed line).

PerCP-Cyanine5.5 Anti-Mouse CD274 (PD-L1, B7-H1) (10F.9G2)

種類 65-1243-U025
通常価格
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説明

TDS | SDS

The 10F.9G2 antibody is specific for mouse CD274, more commonly known as PD-L1 or B7-H1, which acts as a ligand for the T cell co-regulatory receptor PD-1 (CD279). This interaction modulates T cell antigen receptor (TCR) signaling and therefore T cell activation. PD-L1 binding to PD-1 expressed on CD4- CD8- thymocytes participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-L1 may also bind PD-1 following the receptor's inducible expression on activated, mature T cells, where it has been proposed to limit T cell activation. PD-L1 is one of a group of "B7" ligands whose interactions with the CD28 receptor family, also including CTLA-4 (CD152), provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.

The 10F.9G2 antibody may be used as a marker for PD-L1 expression on T and B cells, NK cells and on dendritic cells. It is also widely used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.

Name PerCP-Cyanine5.5 Anti-Mouse CD274 (PD-L1, B7-H1) (10F.9G2)
Cat. No. 65-1243
Alternative Names B7H1, PDL-1, PDL1
Gene ID 60533
Clone 10F.9G2
Isotype Rat IgG2b, κ
Reactivity Mouse
Format PerCP-Cyanine5.5