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C57Bl/6 bone marrow cells were stained with 0.125 ug PE-Cy7 Anti-Hu/Mo CD11b  (60-0112) (solid line) or 0.125 ug PE-Cy7 Rat IgG2b isotype control (dashed line).

PE-Cyanine7 Anti-Human/Mouse CD11b (M1/70)

種類 60-0112-U025
通常価格
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説明

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The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

 

Recent Citations:

Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round JL. Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep. 2021 Nov 2;37(5):109916. doi: 10.1016/j.celrep.2021.109916. PMID: 34731608.

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Name PE-Cyanine7 Anti-Human/Mouse CD11b (M1/70)
Cat. No. 60-0112
Alternative Names Mac-1, integrin α?M, CR3, ITGAM
Gene ID 16409 / 3684
Clone M1/70
Isotype Rat IgG2b, κ
Reactivity Human, Mouse
Cross Reactivity Chimpanzee, Baboon, Cynomolgus, Rhesus
Format PE-Cyanine7
Application Flow Cytometry