Protein-glutamine gamma-glutamyltransferase 2, also known as TGM2, is a multifunctional enzyme involved in various biological processes, including cell growth, differentiation, apoptosis, and tissue repair. It catalyzes protein crosslinking by bonding glutamine and lysine residues. It also functions as a deamidase, GTPase, and protein disulfide isomerase. In macrophages, TGM2 expression is induced by Th2 cytokines and plays an important role in M2 differentiation. These M2 macrophages are involved in anti-inflammatory responses, tissue repair, and remodeling. In addition, TGM2 helps in stabilizing the extracellular matrix and promoting cell adhesion, which are crucial for the proper functioning and differentiation of these macrophages. Dysregulation of TGM2 has been linked to several diseases, such as cancer, neurodegenerative disorders, and fibrosis. Overexpression of TGM2 is associated with tumor progression and chemoresistance, while its role in neurodegeneration involves the formation of protein aggregates.

PRODUCT DETAILS

Clone: 4G3

Antibody Type: Monoclonal

Reactivity: Human, Mouse

Format: TGM2

Host: Mouse

Isotype: IgG1, κ

Applications: ICFC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.