TDS | SDS

The DATK32 antibody is specific for a combinatorial epitope of the mouse integrin αalpha 4/beta 7 (LPAM-1) heterodimer. LPAM-1 is expressed on most mature lymphocytes and sub-populations of thymocytes and bone marrow cells. It is involved in lymphocyte adhesion and migration and is a receptor for several extracellular matrix proteins including VCAM-1, fibronectin, and MAdCAM-1.

DATK32 is reported to induce LPAM-1 dependent lymphocyte aggregation and block adhesion to VCAM-1, fibronectin, and MAdCAM-1.