TDS | SDS

The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).

The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.

Recent Publications:

Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. Cell Rep. 2021 Jun 1;35(9):109210. doi: 10.1016/j.celrep.2021.109210. PMID: 34077737.

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Wiedemann GM, Grassmann S, Lau CM, Rapp M, Villarino AV, Friedrich C, Gasteiger G, O'Shea JJ, Sun JC. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell Rep. 2020 Dec 15;33(11):108498. doi: 10.1016/j.celrep.2020.108498. PMID: 33326784. 

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Diaz-Salazar C, Sun JC. Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses. Cell Rep. 2020 Sep 22;32(12):108186. doi: 10.1016/j.celrep.2020.108186. PMID: 32966792. 

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