Clec4a1 or dendritic cell inhibitory receptor 4 (DCIR4) is a C-type lectin receptor (CLR) which belongs to DC immunoreceptor (DCIR) family. Inhibitory members of DCIR family are type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain. Studies indicate that inhibitory DCIRs play an anti-inflammatory role and that immunopathology related to rheumatoid arthritis and TB infection is driven by their loss. Inhibitory DCIR are found on DCs, B cells, monocytes, macrophages, and neutrophils, but not T or NK cells and relay signal through Src homology region 2 domain-containing phosphatase (SHP). DCIR4, yet to be confirmed to have inhibitory role, is exclusive to non-granulocytic myeloid cells and its expression level can be used to differentiate between patrolling and inflammatory monocytes.

PRODUCT DETAILS

Clone: MH7E7

Antibody Type: Monoclonal

Reactivity: Mouse

Format: PE

Host: Rat

Isotype: IgG1, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

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