The rat monoclonal antibody clone R1-2 binds to mouse CD49d, a 150 kDa glycoprotein member of the integrin αfamily. CD49d is also known as integrin alpha4 (ITGA4). Together with integrin beta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can dimerize with integrin beta7 to form a receptor that binds the mucosal vascular address in the molecule, MAdCAM-1.

PRODUCT DETAILS

Clone: R1-2

Specificity: CD49d

Reactivity: Mouse

Format: PE

Isotype: Rat IgG2b, k

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 1-5 μg/ml. It is recommended that users titrate the antibody to obtain the optimal result for their specific application.

For research use only. Not intended for use in diagnostic procedures.