CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, S-Endo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig superfamily. CD146 is a cell adhesion molecule that plays a role in cell-cell and cell-extracellular matrix interactions and its expression on vascular endothelial basement membranes facilitates TH17 cell entry into tissues. CD146 is strongly expressed by murine vascular endothelial cells, a subset of NK1.1-positive cells, and neutrophils. In mice, CD146 is a marker of natural killer cell maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative marker to detect final stages of NK cell maturation and define NK cell subsets. CD146+ NK cells were found to be less cytotoxic and to produce less IFNγ than CD146- NK cells upon stimulation with target cells or activating antibodies.

PRODUCT DETAILS

Clone: 29-1709

Antibody Type: Monoclonal

Reactivity: Mouse

Format: CD146

Host: Rat

Isotype: IgG2b, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.