The mouse monoclonal antibody clone CB38 binds to human CD36, an 88 kDa glycoprotein (GPIV) expressed on monocytes, platelets, endothelial cells, and some tumor cell lines but not on lymphocytes or granulocytes. CD36 is a key receptor involved in lipid metabolism, inflammation, and atherosclerosis, facilitating the recognition and uptake of oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. It also plays a role in malaria pathogenesis by mediating the cytoadherence of Plasmodium falciparum-infected erythrocytes. As a receptor for thrombospondin, CD36 is the fourth major platelet surface glycoprotein, binding to collagen, thrombospondin, anionic phospholipids, and oxidized LDL.

PRODUCT DETAILS

Clone: CB38

Specificity: CD36

Reactivity: Human

Format: PE

Isotype: Mouse IgM, k

Tested Dilution: 5 µL/Test

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 5 µL per 1 million cells in a staining volume of 100 µL. If whole blood is analyzed, then use 5 µL per 100 µL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application. The content of a vial (0.5 mL) is sufficient for 100 tests.

REFERENCES

1. Alessio M, Greco NJ. et al., 1993. Blood. 82(12):3637-47
2. Alessio M, Roggero S. et al., 1991. Curr Stud Hematol Blood Transfus. 58:182-6
3. Knapp, W. 1989. Oxford University Press:1-1182.

For research use only. Not intended for use in diagnostic procedures.