CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans. CD158a, also known as KIR2DL1, is a 38 kD, two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL1 has been reported to bind certain HLA-C antigens on target cells (HLA-C*02, HLA-C*04, HLAC*06, for example).

PRODUCT DETAILS

Clone: S22039A

Antibody Type: Monoclonal

Reactivity: Human

Format: CD158a

Host: Mouse

Isotype: IgG1, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.