ショッピングカート
In Vivo Ready™ Anti-Mouse CD4 (GK1.5)

In Vivo Ready™ Anti-Mouse CD4 (GK1.5)

種類 40-0041-U100
通常価格
task_alt カートに追加されました。
カートを見る または ショッピングを続ける
説明

The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.

The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will “compete” for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.

Name In Vivo Ready™ Anti-Mouse CD4 (GK1.5)
Cat. No. 40-0041
Data Sheets TDS | SDS
Alternative Names L3T4, T4
Gene ID 12504
Clone GK1.5
Isotype Rat IgG2b, κ
Reactivity Mouse
Cross Reactivity Syrian Hamster
Format In Vivo Ready™
Application FC - Validated
FA, IHCF, IP - Reported in literature, not validated in house

For Research Use Only. Not intended for use in diagnostic procedures.