CD49d is a 150 kD glycoprotein, also known as integrin α₄ or VLA-4 α chain. It is expressed as a heterodimer with either of two β chains, β₁ or β₇. The α₄β₁ integrin (also known as VLA-4, CD49d/CD29) is expressed on peripheral T and B lymphocytes, thymocytes, and monocytes, while the α₄β₇ integrin (also known as LPAM-1) is expressed on peripheral lymphocytes. The α₄β₁ and α₄β₇ integrins mediate cell-cell and cell-matrix interactions by interacting with the ligands CD106 (VCAM-1), MAdCAM-1, and fibronectin. Soluble MRα4-1 antibody can partially inhibit in vitro binding of VCAM-1 and mast cells to fibronectin and inhibit mast cell degranulation. Immobilized MRα4-1 antibody can enhance mast cell degranulation in vitro.

PRODUCT DETAILS

Clone: MRα4-1

Antibody Type: Monoclonal

Reactivity: Rat

Format: FITC

Host: Mouse

Isotype: IgG2a, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.