FITC Anti-Mouse CD19 (1D3)
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説明
The 1D3 antibody reacts with mouse CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 and CD81, in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells. The 1D3 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.
Recent Citations:
Hinke DM, Andersen TK, Gopalakrishnan RP, Skullerud LM, Werninghaus IC, Grødeland G, Fossum E, Braathen R, Bogen B. Antigen bivalency of antigen-presenting cell-targeted vaccines increases B cell responses. Cell Rep. 2022 May 31;39(9):110901. doi: 10.1016/j.celrep.2022.110901. PMID: 35649357.
Name | FITC Anti-Mouse CD19 (1D3) |
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Cat. No. | 35-0193 |
Alternative Names | Leu-12, B4 |
Gene ID | 12478 |
Clone | 1D3 |
Isotype | Rat IgG2a, κ |
Reactivity | Mouse |
Format | FITC |
Application | Flow Cytometry |