The mouse monoclonal antibody clone CB38 binds to human CD36, an 88 kDa glycoprotein (GPIV) expressed on monocytes, platelets, endothelial cells, and some tumor cell lines but not on lymphocytes or granulocytes. CD36 is a key receptor involved in lipid metabolism, inflammation, and atherosclerosis, facilitating the recognition and uptake of oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. It also plays a role in malaria pathogenesis by mediating the cytoadherence of Plasmodium falciparum-infected erythrocytes. As a receptor for thrombospondin, CD36 is the fourth major platelet surface glycoprotein, binding to collagen, thrombospondin, anionic phospholipids, and oxidized LDL.

PRODUCT DETAILS

Clone: CB38

Specificity: CD36

Reactivity: Human

Format: cFluor^® V670

Isotype: Mouse IgM, k

Tested Dilution: 5 µl/Test

Application: Flow Cytometry

Storage: 2-8°C protected from light. Do not freeze

Formulation: Phosphate-buffered saline, pH 7.2, containing 0.1% PEG 3350, 0.1% Pluronic F-68, 0.05% Tween-20, 0.09% sodium azide and 1% BSA (BSA Country of Origin USA)

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Each lot of this antibody is quality control tested using flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 μL per 1 million cells in a staining volume of 100 μL. If whole blood is analyzed, then use 5 μL per 100 μL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application.

Please briefly centrifuge the reagent vial before use.

Use appropriate personal protective equipment per the product safety data sheet when using this product.

REFERENCES

1. Alessio M, Greco NJ. et al., 1993. Blood. 82(12):3637-47
2. Alessio M, Roggero S. et al., 1991. Curr Stud Hematol Blood Transfus. 58:182-6
3. Knapp, W. 1989. Oxford University Press:1-1182.

For Research Use Only. Not intended for use in diagnostic procedures.

Cytek^® cFluor^® V670 is StarBright^™ Violet 670 Dye, manufactured and provided by Bio-Rad, Inc.

StarBright is a trademark of Bio-Rad Laboratories, Inc. in certain jurisdictions. StarBright Dyes are manufactured and provided by Bio-Rad under an Agreement between Bio-Rad supplied to Cytek, being subject to certain conditions.

cFluor^® V670 is a tandem dye. Caution – Tandem dyes may show changes in their emission spectra with prolonged exposure to light or fixatives.” at the end on its own line.