Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide and do not respond to growth-promoting stimuli. It is triggered by a variety of cellular stressors, including environmental factors like ionizing radiation or exposure to chemotherapeutic drugs, oxidative stress, DNA damage, mitochondrial dysfunction, and oncogene activation. Senescence-Associated β-galactosidase (SA-β-gal), a result of altered lysosomal activity, is a hallmark of cellular senescence. Cellular Senescence Kit Red uses a fluorogenic beta-Gal substrate that readily enters into live cells, where it gets cleaved by SA-β-gal inside cells, generating strong red fluorescence. It provides higher sensitivity compared to X-gal staining, a colorimetric method widely available and used to detect Senescence-associated beta-galactosidase (SA-beta-gal) in senescent cells.

PRODUCT DETAILS

Clone: None

Antibody Type: None

Reactivity: Mouse, Human

Format: None

Host: None

Isotype: None

Applications: FC - Quality tested Live cell imaging - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.