TDS | SDS

The OX-86 monoclonal antibody reacts with mouse CD134, a 50kD type 1 integral membrane glycoprotein and a member of the TNF-α receptor superfamily. CD134 is also known as OX40 and is expressed on activated CD4 and CD8 T cells. CD134 is the receptor for CD252 (OX40 ligand) and the interaction of this receptor-ligand pair is implicated in T-dependent humoral responses as well as numerous aspects of T cell expansion, survival and memory. Additionally, CD134 seems to play a significant role in the pathogenesis of some autoimmune diseases.