B cell linker protein (BLNK), a member of the SLP-76 family, is an adapter molecule that plays important roles in B cell antigen receptor (BCR) engagement and B cell activation. Cross-linking of the BCR stimulates various downstream signaling pathways involved in cell proliferation and apoptosis. Intracellular protein tyrosine kinases such as Syk and Lyn have been implicated in BCR signal transduction and are thought to play an important role in B cell development. Phosphorylation of human BLNK at tyrosines 84, 178, and 189 (Y84, Y178, and Y189) creates docking sites for effector proteins GRB2, Vav, Nck and PLCγ2, which in turn leads to the activation of downstream signaling pathways. Phosphorylation of tyrosine 96 (Tyr96) facilitates BTK binding and plays a critical role in B cell maturation.

PRODUCT DETAILS

Clone: A19008A

Antibody Type: Monoclonal

Reactivity: Human

Format: BLNK Phospho Tyr96

Host: Mouse

Isotype: IgG1, κ

Applications: ICFC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.