The mouse monoclonal antibody 6D4 recognizes a common extracellular epitope on MICA and MICB glycoproteins, transmembrane ligands of CD314 (NKG2D), and is able to block CD314-mediated activation of NK cells and cytotoxic T cells.

PRODUCT DETAILS

Clone: 6D4

Specificity: MICA/MICB

Reactivity: Human

Format: Alexa Fluor™ 700

Isotype: Mouse IgG2a

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 1-5 μg/ml. It is recommended that users titrate the antibody to obtain the optimal result for their specific application.

REFERENCES

1. Ghadially H, et al. 2017. Br J Cancer 116:1208-1217.
2. Del Toro-Arreola S, et al. 2011. Cancer Cell Int 11:15.
3. Carreno BM, et al. 2009. Clin Cancer Res 15:3277-86.
4. Sester M, et al. 2010. J Immunol 184:255-67.
5. Xu X, et al. 2006. J Clin Endocrinol Metab 91:2704-12.
6. Steinle A, et al. 2001. Immunogenetics 53:279-87.
7. Groh V, et al. 1996. Proc Natl Acad Sci U S A 93:12445-50.

For research use only. Not intended for use in diagnostic procedures.