SP1 belongs to the transcription factor SP/KLF family, which contains three zinc finger domains that can bind to GC boxes and regulate transcription of a variety of molecules. SP1 regulates efferent gene transcription positively and negatively, participating broadly in cellular development and physiological functions as a generally expressed transcription factor. Post-translational modifications, including phosphorylation, glycosylation, acetylation, ubiquitylation, and SUMOylation, highly regulate SP1’s function and stability. SP1 is required to develop and differentiate early embryo, placenta, and sperm cells. SP1 is highly expressed in multiple cancers including breast, stomach, pancreas, lung, and brain. SP1 promotes tumor cell proliferation, inactivates cell death, and facilitates immune escape.

PRODUCT DETAILS

Clone: W21043E

Antibody Type: Monoclonal

Reactivity: Human, Mouse

Format: SP1

Host: Rat

Isotype: IgG2a, κ

Applications: IHC-P - Quality tested ICC - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.