Alexa Fluor® 647 anti-Oligodendrocyte Marker O1
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説明
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). Similar to the Schwann cells in the peripheral nervous system (PNS), their function is to provide support and isolation to neuronal axons. Their importance has been denoted on de-myelinating diseases such as multiple sclerosis, amyotrophic lateral sclerosis, periventricular leukomalacia, and also, they have been associated with dementia, schizophrenia, cognitive impairment, and bipolar disorder. Oligodendrocytes develop during embryogenesis; however, a small proportion of progenitor stem cells are present in the adult brain. Thus, three stages of differentiation can be identified in the cerebral white matter, and specific markers have been associated which each particular stage. Galactocerebroside O1 (marker O1) is one of the major galactosphingolipids components of oligodendrocytes plasma membrane. It is produced from late immature non-myelinating oligodendrocytes to mature myelinating oligodendrocytes, and together with expression of CNPase, it has been widely used as characteristic marker for these specific differentiation stages.
PRODUCT DETAILS
Clone: O1
Antibody Type: Monoclonal
Reactivity: Human, Rat
Format: Alexa Fluor 647
Host: Mouse
Isotype: IgM, κ
Applications: IHC-P - Quality tested ICC, ICFC - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.