The 14-4-4S antibody reacts with the I-E^k MHC class II alloantigen. These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2^k bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins. The 14-4-4S antibody cross-reacts with cells from mice of the H-2^d, H-2^p, and H-2^r haplotypes and the rat MHC class II antigen RT1D. Cells from mice of the H-2^b, H-2^f, H-2^q, and H-2^s haplotypes do not express I-E antigen. The 14-4-4S antibody has been reported to block antigen presentation and induce differentiation of mouse cells bearing I-E^k.

PRODUCT DETAILS

Clone: 14-4-4S

Antibody Type: Monoclonal

Reactivity: Mouse, Rat

Format: Alexa Fluor 647

Host: Mouse

Isotype: (C3H.SW) IgG2a, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.