Histone 3, also known as H3, is a core component of the nucleosome that serves to wrap and compact DNA into chromatin. Histones therefore, limit the accessibility of DNA, providing mechanisms for transcription regulation, DNA repair and replication and chromosomal stability. H3 is part of the nucleosome, comprised of an octameric complex with H2A, H2B, and H4 proteins. H3 has been demonstrated to be phosphorylated by the action of MLTK-α (mixed linage kinase-like mitogen activated protein triple kinase α) in response to ultraviolet B light and epidermal growth factor, as well as Aurora-B during mitosis. Phosphorylation of H3.3 Ser31 occurs during mitosis and is a chromatin mark associated with heterochromatin. This phosphorylation coincides with chromosome condensation initiated at prophase and disappears at late anaphase.

PRODUCT DETAILS

Clone: 1A8G10

Antibody Type: Monoclonal

Reactivity: Human

Format: Alexa Fluor 647

Host: Mouse

Isotype: IgG2b, κ

Applications: ICFC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.