The CD3ε chain of the T-cell receptor (TCR)-CD3 complex is a type I membrane protein that plays a critical role in antigen recognition, TCR signal transduction and T-cell activation following binding to the peptide/MHC antigen complex. CD3ε is expressed by all mature T cells and forms a heteromeric complex with CD3 γ, δ and ζ chains, and either α/β or γ/δ chains of the TCR heterodimer. Upon activation, CD3 undergoes a conformational change, leading to exposure of the proline rich sequence in CD3ε and recruitment of Lck. CD3 is also important in T cell development, and deficiency of this gene has been associated with severe immunodeficiency.

PRODUCT DETAILS

Clone: W23186F

Antibody Type: Monoclonal

Reactivity: Human, Mouse

Format: CD3epsilon

Host: Rat

Isotype: IgG2a, κ

Applications: IHC-P - Quality tested ICFC - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.