Alexa Fluor® 594 anti-ATF7
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説明
Activating Transcription Factor 7 (ATF7) is a member of the ATF/cAMP response element-binding protein family. Among these ATF family members, ATF7 shares highly structurally conserved N-terminal activation domain and the C-terminal DNA binding/dimerization domain with ATF2. ATF7 has no intrinsic transcriptional activity and forms functional heterodimers with c-Jun or c-Fos proteins. Upon stimulation, such as pathogen infection and various stresses, ATF7 is phosphorylated by stress‐activated protein kinase p38 at Thr51 and Thr53 and in turn resulted in the activation of ATF7 target genes. In the absence of stress, ATF silences targets genes by recruiting histone methyltransferases, leading to the formation of heterochromatin. ATF7 deficient mice die soon after birth. Double knockout mutations of ATF2 and ATF7 lead to prenatal lethality with abnormalities in liver and heart.
PRODUCT DETAILS
Clone: W16152A
Antibody Type: Monoclonal
Reactivity: Human, Mouse
Format: Alexa Fluor 594
Host: Rat
Isotype: IgG2a, κ
Applications: ICC - Quality tested
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.