Vimentin are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is a widely expressed and highly conserved 54 kD protein that is constitutively expressed in mesenchymal cells, endothelial cells lining blood vessels, renal tubular cells, macrophages, neutrophils, fibroblasts, and leukocytes1,2. Vimentin is used as a marker of mesenchymal cells to distinguish them from epithelial cells3. Increased vimentin expression is frequently used as an EMT marker in cancer4. Autoantibodies to vimentin are commonly found in patients with autoimmune diseases such as Lupus5 and rheumatoid arthritis6, and also found after transplantation7.

PRODUCT DETAILS

Clone: O91D3

Antibody Type: Monoclonal

Reactivity: Human

Format: Alexa Fluor 488

Host: Mouse

Isotype: IgG2a, κ

Applications: ICC - Quality tested ICFC, IHC-P - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

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