RBFox3, commonly referred to as NeuN, is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name RBFox is an acronym of 'Feminizing locus on X'. The Fox protein and its 3 mammalian homologues are all about 46 kD proteins, each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. RBFox3 is a protein which has a function in RNA splicing and is expressed heavily and specifically in neuronal nuclei. The antibody reveals strong nuclear and distal cytoplasmic staining for RBFox3/NeuN and the complete absence of staining of astrocytes and other kinds of non-neuronal cells. This RBFox3/NeuN antibody is therefore an excellent marker of neuronal cells.

PRODUCT DETAILS

Clone: W18230A

Antibody Type: Monoclonal

Reactivity: Human, Mouse

Format: Alexa Fluor 488

Host: Rat

Isotype: IgG2a, κ

Applications: IHC-F - Quality tested IHC-P - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

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