The mouse monoclonal antibody clone 10.1 binds to human CD64 (FcRI), a 75 kDa type I transmembrane protein. CD64 functions as a high-affinity receptor for IgG, facilitating antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, and cytokine production. CD64 is expressed on monocytes, macrophages, dendritic cells, and activated granulocytes, while mature granulocytes and lymphocytes lack expression. Increased expression of CD64 on neutrophils may be indicative of an active immune response to bacterial infection or sepsis in research applications. The 10.1 clone reportedly blocks the binding of immunoglobulin to FcRI.

PRODUCT DETAILS

Clone: 10.1

Specificity: CD64

Reactivity: Human

Format: Purified

Isotype: Mouse IgG1

Application: FC, IP, WB, IHC-P, ICC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: Recommended dilution: 1-5 μg/ml.

For research use only. Not intended for use in diagnostic procedures.