The mouse monoclonal antibody clone M80 binds to human CD141, a 75-kDa type I membrane glycoprotein. CD141, also known as thrombomodulin, BDCA-3, and fetomodulin. CD141 binds to its ligand, thrombin, to form a thrombin-thrombomodulin complex. This complex activates protein C and initiates the Protein C anticoagulant pathway. When bound to CD141, thrombin loses its ability to activate several pro-coagulant proteins. The molecule is expressed on macrophages, monocytes, dendritic cells, and vascular endothelial cells.

PRODUCT DETAILS

Clone: M80

Specificity: CD141

Reactivity: Human

Format: Purified

Isotype: Mouse IgG1, k

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: Recommended dilution: 1-5 µg/ml

For research use only. Not intended for use in diagnostic procedures.