{"product_id":"purified-anti-human-igd-ia6-2","title":"Purified Anti-Human IgD (IA6-2)","description":"\u003cp\u003eThe IA6-2 monoclonal antibody reacts with the heavy chain of human Immunoglobulin D (IgD), a type I transmembrane glycoprotein and member of the immunoglobulin superfamily. IgD is co-expressed with membrane IgM on the surface of mature naïve B cells, where both isotypes associate with the Igα\/Igβ (CD79a\/CD79b) signaling heterodimer to form the B cell antigen receptor (BCR) complex. Engagement of the IgD-BCR by antigen mediates signal transduction that fine-tunes B cell activation, selection, and tolerance, complementing rather than duplicating IgM-BCR signaling. IgD expression is lost following isotype class switching, and a soluble form of IgD circulates at low levels in serum, where it has also been implicated in mucosal innate immune defense through interactions with basophils and mast cells.\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePRODUCT DETAILS\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone\u003c\/b\u003e: IA6-2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecificity\u003c\/b\u003e: IgD\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat\u003c\/b\u003e: Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e: Mouse IgG2a, k\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: FC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: 2-8°C protected from light.\u003cb\u003eDo not freeze\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide\u003c\/p\u003e\u003cp\u003e\u003cb\u003eData Sheets: \u003c\/b\u003e\u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/TDS\/cfluor\/project_elva_2k\/R8-91061+Rev.+A_TDS_Purified+Anti-Human+IgD+(IA6-2).pdf\" target=\"_blank\"\u003eTDS\u003c\/a\u003e | \u003ca href=\"https:\/\/cytek-web.s3.us-east-1.amazonaws.com\/cytekbio.com\/documentation-center\/SDS\/R9-70004+Rev.+E_SDS+fluorescent+conjugated+Abs.pdf\" target=\"_blank\"\u003eSDS\u003c\/a\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eRECOMMENDED USAGE\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eFlow cytometry: Recommended dilution: 2-4 μg\/ml.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\u003col\u003e\n\u003cli\u003eGeisberger, R. et al. 2006. Immunology 118: 429–437.\u003c\/li\u003e\n\u003cli\u003eChen, K. and Cerutti, A. 2011. Curr. Opin. Immunol. 23: 345–352.\u003c\/li\u003e\n\u003cli\u003eGutzeit, C. et al. 2018. Eur. J. Immunol. 48: 1101–1113.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eFor research use only. Not intended for use in diagnostic procedures.\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e","brand":"Cytek Biosciences","offers":[{"title":"100 µg","offer_id":67679908528164,"sku":"R7-91061","price":133.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1654\/6801\/files\/R7-91061_FC_Profile.png?v=1792021412","url":"https:\/\/cytekbio.com\/products\/purified-anti-human-igd-ia6-2","provider":"Cytek Biosciences","version":"1.0","type":"link"}