{"product_id":"purified-anti-human-cd11c-bu15","title":"Purified Anti-Human CD11c (BU15)","description":"\u003cp\u003eThe mouse monoclonal antibody clone BU15 binds to human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin α-receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g., fibrinogen (cell-matrix). In addition, integrin α's are active signaling receptors that recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin α-receptors consist of distinct combinations of integrin α-chains, which are differentially expressed. Integrin alpha X (CD11c) assembles with integrin beta-2 (CD18) into a receptor known as CR4, which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells. CD11c is prominently expressed on tissue macrophages and detected on activated neutrophils, granulocytes, some types of activated T cells, and intestinal intraepithelial lymphocytes (IEL).\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePRODUCT DETAILS\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone\u003c\/b\u003e: BU15\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecificity\u003c\/b\u003e: CD11c\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat\u003c\/b\u003e: Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e: Mouse IgG1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: FC, IP\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: 2-8°C protected from light.\u003cb\u003eDo not freeze\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide\u003c\/p\u003e\u003cp\u003e\u003cb\u003eData Sheets: \u003c\/b\u003e\u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/TDS\/cfluor\/project_elva_2k\/R8-91623+Rev.+A_TDS_Purified+Anti-Human+CD11c+(BU15).pdf\" target=\"_blank\"\u003eTDS\u003c\/a\u003e | \u003ca href=\"https:\/\/cytek-web.s3.us-east-1.amazonaws.com\/cytekbio.com\/documentation-center\/SDS\/R9-70004+Rev.+E_SDS+fluorescent+conjugated+Abs.pdf\" target=\"_blank\"\u003eSDS\u003c\/a\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eRECOMMENDED USAGE\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eFlow cytometry: Recommended dilution: 1-4 μg\/ml.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\u003col\u003e\n\u003cli\u003eSchlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.\u003c\/li\u003e\n\u003cli\u003eKnapp W, et al. 1989. Leucocyte Typing IV Oxford University Press. New York.\u003c\/li\u003e\n\u003cli\u003eMcMichael A, et al. Eds. 1987. Leucocyte Typing III Oxford University Press. New York.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eFor research use only. Not intended for use in diagnostic procedures.\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e","brand":"Cytek Biosciences","offers":[{"title":"100 µg","offer_id":67679884443684,"sku":"R7-91623","price":186.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1654\/6801\/files\/R7-91623_FC_Profile.png?v=1792021010","url":"https:\/\/cytekbio.com\/products\/purified-anti-human-cd11c-bu15","provider":"Cytek Biosciences","version":"1.0","type":"link"}