The CD7-6B7 monoclonal antibody binds to human CD7, a 40-kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. CD7, also known as GP40, is found on T cells, NK cells, thymocytes, and pre-B cells¹. CD7 is called T cell leukemia antigen for its expression on acute lymphocytic leukemia and some acute myeloid leukemia². Studies show that cross-linking of CD7 significantly increases CD7-associated PI3-kinase activity, suggesting the antigen’s functional role in inducing calcium flux in T lymphocytes, and T and NK cell activation³. The antibody was conjugated to a fluorophore and purified by affinity chromatography.

PRODUCT DETAILS

Clone:                  CD7-6B7

Reactivity:          Human

Format:                cFluor® V420 

Isotype:               Mouse IgG2a, κ

Tested Dilution:  5 μL / test

Application:        Flow Cytometry

Storage:               2-8°C and protected from Light. Do not freeze

Formulation:      Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA).

Data Sheets:       IFU SDS

REFERENCES

1. Rabinowich H, 1994. J Immunol. 152(2):517-526
2. Aruffo A, et al. 1987. EMBO J. 6(11):3313-3316
3. Lee DM, et al. 1996. Int Immunol. 8(8):1195-1203

 This product is intended for in vitro diagnostic use to identify human cells expressing CD7 antigen molecules in countries where the regulatory approval has been obtained from the local regulatory authorities.