The SK7 monoclonal antibody binds to human epsilon chain of the CD3 antigen/T-cell antigen receptor, a 20 to 30-kDa protein complex. This complex contains a CD3γ, a CD3δ, a CD3ζ (CD247), two CD3ε, and a T-cell receptor (αβ or γδ) heterodimer¹. CD3 is found on all mature T cells, NK T cells and thymocytes. It play a role in recognizing antigen, activating cytotoxic T cell and T helper cell, and signal transduction². The antibody was conjugated to a fluorophore and purified by affinity chromatography.

PRODUCT DETAILS

Clone:                  SK7

Reactivity:          Human, Chimpanzee

Format:              cFluor^® V420

Isotype:               Mouse IgG1, κ

Tested Dilution:  5 μL / test

Application:        Flow Cytometry

Storage:               2-8°C and protected from Light. Do not freeze

Formulation:      Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA).

Data Sheets:      TDS SDS

REFERENCES

1. Dong, D., et al. 1981. Nature. 573, 546–552
2. Weiss A, et al. 1991. Semin Immunol. (5):313-24

 This product is intended for in vitro diagnostic use to identify human cells expressing CD3 antigen molecules in countries where the regulatory approval has been obtained from the local regulatory authorities.