cFluor® R780 Anti-Human CD8 (SK1)
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The SK1 monoclonal antibody binds to human CD8a, a 32-34-kDa type I glycoprotein that forms either as an α/α homodimer α/β heterodimer with its isoform CD8b. CD8 is found on thymocytes, a subset of peripheral blood T cells, majority expressing α/β heterodimer, and NK cells, majority expressing α/α homodimer1. CD8 plays a role in antigen recognition and class I MHC-restricted T cell development. CD8 functions are associated with two domains of CD8a. CD8a ectodomain binding to the α3 domain of MHC class I increases the adhesion between CD8+ T lymphocytes and target cells. The cytoplasmic tail binding to the tyrosine kinase p56lck contributes to signal transduction and T cell activation2,3. The antibody was conjugated to a fluorophore and puriﬁed by afﬁnity chromatography.
Reactivity: Human, African Green, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus, Sooty Mangabey
Format: cFluor® R7801
Isotype: Mouse IgG1, κ
Tested Dilution: 5 μL / test
Application: Flow Cytometry
Storage: 2-8°C and protected from Light. Do not freeze
Formulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA).
- Cole DK, et al. 2004. Cell Mol Immunol. 1(2):81-8
- Kern Petra S. et al. 1998. Immunity. 519-530
- Veillette A. et al. 1988. Cell. 55:301-308
This product is intended for in vitro diagnostic use to identify human cells expressing CD8 antigen molecules in countries where the regulatory approval has been obtained from the local regulatory authorities.
1cFluor® R780 is a tandem dye made with APC. Caution: Tandem dyes may show changes in
their emission spectra with prolonged exposure to light or fixatives.