The CD7-6B7 monoclonal antibody binds to human CD7, a 40-kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. CD7, also known as GP40, is found on T cells, NK cells, thymocytes, and pre-B cells¹. CD7 is called T cell leukemia antigen for its expression on acute lymphocytic leukemia and some acute myeloid leukemia². Studies show that cross-linking of CD7 significantly increases CD7-associated PI3-kinase activity, suggesting the antigen’s functional role in inducing calcium flux in T lymphocytes, and T and NK cell activation³. The antibody was conjugated to a fluorophore and purified by affinity chromatography.

PRODUCT DETAILS

Clone:                  CD7-6B7

Reactivity:          Human

Format:               cFluor® R668¹

Isotype:               Mouse IgG2a, κ

Tested Dilution:  5 μL / test

Application:        Flow Cytometry

Storage:               2-8°C and protected from Light. Do not freeze

Formulation:       Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA).

Data Sheets:       IFU SDS

REFERENCES

1. Rabinowich H, 1994. J Immunol. 152(2):517-526.
2. Aruffo A, et al. 1987. EMBO J. 6(11):3313-3316.
3. Lee DM, et al. 1996. Int Immunol. 8(8):1195-1203.

This product is intended for in vitro diagnostic use to identify human cells expressing CD7 antigen molecules in countries where the regulatory approval has been obtained from the local regulatory authorities.

¹cFluor® R668 is equivalent to CF®647 manufactured and provided by Biotium, Inc. under an Agreement between Biotium and Cytek (LICENSEE). The manufacture, use, sale, offer for sale, or import of the product is covered by one or more of the patents or pending applications owned or licensed by Biotium. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser’s own internal research. No right under any other patent claim, no right to perform any patented method, and no right to perform commercial services of any kind, including without limitation reporting the results of purchaser's activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel.

These products are for research use only and are not intended for diagnostic use.