The 104D2 monoclonal antibody binds to human CD117, a 145-kDa protein tyrosine kinase. CD117, also known as c-kit, is the receptor for the hematopoietic cytokine stem cell factor (SCF) expressed on hematopoietic progenitor cell subsets, thymocytes, mast cells hepatocytes and histiocytes. It is
also commonly expressed on acute myeloid leukemias (AML). When bound to stem cell factor (c-kit ligand), CD117 activates tyrosine kinase and is involved in cell survival, proliferation and differentiation. The antibody is conjugated to a fluorophore and purified by affinity chromatography.

PRODUCT DETAILS

Clone:                 104D2

Reactivity:          Human, Cynomolgus, Bovine

Format:             cFluor® BYG610¹

Isotype:               Mouse IgG1, κ

Tested Dilution:  5 μL / test

Application:        Flow Cytometry

Storage:               2-8°C and protected from Light. Do not freeze

Formulation:      Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA).

Data Sheets:       IFU SDS

REFERENCES

1. Simmons PJ, et al. 1994. Exp Hematol. 22(2):157-165.
2. Escribano L, et al. 1998. Leuk Lymphoma. 30(5-1): 459–466.
3. Blume-Jensen P, et al. 1991. EMBO J. 10(13): 4121–4128.

This product is intended for in vitro diagnostic use to identify human cells expressing CD117 antigen molecules in countries where the regulatory approval has been obtained from the local regulatory authorities. 

¹cFluor® BYG610 is a tandem dye made with R-PE. Caution: Tandem dyes may show changes in their emission spectra with prolonged exposure to light or fixatives.