The 5.1H11 monoclonal antibody binds to human CD56, a 120 to 180-kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Depending on the cytoplasmic domain, CD56 exists in three main isoforms: NCAM-120, NCAM-140, and NCAM-180¹. CD56, also known as NCAM (Neural Cell Adhesion Molecule), Leu-19 and NKH1, is present on NK and NKT cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Aberrant CD56 expression is observed in a range of hematological malignancies such as multiple myeloma and leukemia² as well as in solid tumors such as lung cancer, ovarian cancer, and neuroblastoma³. The antibody was conjugated to a fluorophore and purified by affinity chromatography.

PRODUCT DETAILS

Clone:                  5.1H11

Reactivity:         Human

Format:              cFluor® BYG575

Isotype:               Mouse IgG1, κ

Tested Dilution:  5 μL / test

Application:        Flow Cytometry

Storage:               2-8°C and protected from Light. Do not freeze

Formulation:      Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA).

Data Sheets:       IFU SDS

REFERENCES

1. Van Acker HH, et al. 2017. Front Immunol. 8:892
2. Crossland DL, et al. 2018. Oncogene. 37(27):3686-3697
3. Seidenfaden R, et al. 2006. Neurochem Int. 49(1):1-11

This product is intended for in vitro diagnostic use to identify human cells expressing CD56 antigen molecules in countries where the regulatory approval has been obtained from the local regulatory authorities.