{"product_id":"biotin-anti-human-hla-dr-l243","title":"Biotin Anti-Human HLA-DR (L243)","description":"\u003cp\u003eThe mouse monoclonal antibody clone L243 binds to the human HLA-DR antigen, a 36 kDa alpha heavy chain, and a 27 kDa beta light chain heterodimeric cell surface glycoprotein in the transmembrane major histocompatibility complex 2 (MHC II) family. HLA-DR, also known as human leukocyte antigen DR isotype, is present on the surface of antigen-presenting cells including, B cells, dendritic cells, macrophages, monocytes, and activated T cells. MHC class II regulates the immune system by playing a critical role in binding and presenting antigen-derived peptides to peptide-MHC II-specific CD4 T cells. The L243 clone identifies HLA-DR molecules, whether peptide-loaded or unoccupied. It does not exhibit cross-reactivity with HLA-DP and HLA-DQ. Clone L243 interacts with a conformational epitope on HLA-DRα, contingent upon the proper folding of the αβ heterodimer.\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePRODUCT DETAILS\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone\u003c\/b\u003e: L243\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecificity\u003c\/b\u003e: HLA-DR\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e: Human, African Green Monkey, Baboon, Chimpanzee, Cynomolgus Monkey, Dog, Common Marmoset, Rhesus Macaque, Squirrel Monkey\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat\u003c\/b\u003e: Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e: Mouse IgG2a, k\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: IHC-P, ICC, IP, FC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: 2-8°C protected from light.\u003cb\u003eDo not freeze\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide\u003c\/p\u003e\u003cp\u003e\u003cb\u003eData Sheets: \u003c\/b\u003e\u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/TDS\/cfluor\/project_elva_2k\/R8-92913+Rev.+A_TDS_Biotin+Anti-Human+HLA-DR+(L243).pdf\" target=\"_blank\"\u003eTDS\u003c\/a\u003e | \u003ca href=\"https:\/\/cytek-web.s3.us-east-1.amazonaws.com\/cytekbio.com\/documentation-center\/SDS\/R9-70004+Rev.+E_SDS+fluorescent+conjugated+Abs.pdf\" target=\"_blank\"\u003eSDS\u003c\/a\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eRECOMMENDED USAGE\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eFlow cytometry: Recommended dilution: 1-5 μg\/ml.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\u003col\u003e\n\u003cli\u003eKnapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.\u003c\/li\u003e\n\u003cli\u003eBarclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.\u003c\/li\u003e\n\u003cli\u003eMarsik C, et al. 2003. Shock 20:493-6.\u003c\/li\u003e\n\u003cli\u003eYoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97-100.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eFor research use only. Not intended for use in diagnostic procedures.\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e","brand":"Cytek Biosciences","offers":[{"title":"100 µg","offer_id":67679805210660,"sku":"R7-92913","price":239.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1654\/6801\/files\/R7-92913_FC_Profile.png?v=1792020068","url":"https:\/\/cytekbio.com\/products\/biotin-anti-human-hla-dr-l243","provider":"Cytek Biosciences","version":"1.0","type":"link"}