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B Cells

B Cells

Description

This primary lymphocyte type develops in the bone marrow and circulates in the periphery to provide immune surveillance. B cells recognize antigen via a specific membrane-bound immunoglobulin which acts as a B cell surface receptor (BCR). Activation of the BCR, along with cell surface co-stimulatory molecules including CD19, drives proliferation and development of progeny “plasma” cells that bear and secrete antibodies of identical specificity.