{"product_id":"alexa-fluor-647-anti-p53-phospho-ser15-recombinant-p53s15-1c11-rec","title":"Alexa Fluor® 647 anti-p53 Phospho (Ser15) Recombinant","description":"\u003cp\u003eThe p53 transcription factor is a tumor suppressor which regulates genome stability via the cell cycle, DNA repair, apoptosis, and senescence. It is activated in response to various cellular stresses including DNA damage. Mutations in TP53 gene are found in approximately half of all human cancers, making it one of the most mutated genes in cancer. These mutations often lead to loss of tumor-suppressing functions, contributing to uncontrolled cell proliferation and tumor development. Phosphorylation at Serine 15 is particularly important for p53 activation and function. This modification, often triggered by DNA damage, enhances p53 stability and its ability to activate target genes involved in cell cycle arrest and apoptosis. Without this phosphorylation, p53 ability to respond to stress signals and prevent tumorigenesis is significantly impaired.\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePRODUCT DETAILS\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone:\u003c\/b\u003e P53S15-1C11.Rec\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAntibody Type:\u003c\/b\u003e Recombinant\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity:\u003c\/b\u003e Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat:\u003c\/b\u003e p53 Phospho Ser15\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost:\u003c\/b\u003e Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype:\u003c\/b\u003e IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications:\u003c\/b\u003e ICFC - Quality tested ICC - Verified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRegulatory Status:\u003c\/b\u003e RUO\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eData Sheets:\u003c\/strong\u003e \u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/TDS\/biolegend\/alexa-fluor-647-anti-p53-phospho-ser15-recombinant-p53s15-1c11-rec-27755+(TDS).pdf\" target=\"_blank\"\u003eTDS\u003c\/a\u003e | \u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/SDS\/biolegend\/Pure_Conjugated_Antibodies_SDS_United_States_English_V2.pdf\" target=\"_blank\"\u003eSDS\u003c\/a\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eNote to Purchaser: \u003c\/strong\u003eThis product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.\u003c\/p\u003e","brand":"BioLegend","offers":[{"title":"25 µg","offer_id":51193991856164,"sku":"640753","price":170.0,"currency_code":"USD","in_stock":true},{"title":"100 µg","offer_id":51193991888932,"sku":"640754","price":465.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/cytekbio.com\/products\/alexa-fluor-647-anti-p53-phospho-ser15-recombinant-p53s15-1c11-rec","provider":"Cytek Biosciences","version":"1.0","type":"link"}