{"product_id":"alexa-fluor-647-anti-dbn1-w21139f","title":"Alexa Fluor® 647 anti-DBN1","description":"\u003cp\u003e\u003c\/p\u003e\u003cp\u003eDrebrin (DBN1) is an actin-binding protein that was identified as a developmentally regulated protein expressed in the brain. Drebrin interacts with microtubules and is localized to focal adhesions, adherens junctions, gap junctions, immunological synapses, and neuronal synapses to modulate cellular processes such as cell migration, cell process formation, cancer metastasis, and spermatogenesis. There are two isoforms of mammals as a result of alternative splicing: Drebrin A (adult) and Drebrin E (embryonic). The expression of Drebrin A is highly specific to neurons and regulates the reorganization of actin filaments and thus contributes to memory, whereas Drebrin E is expressed in various tissues. Studies have shown that a decrease in the amount of Drebrin protein in the brain is thought to be a factor contributing to the pathogenesis of dementia in Alzheimer's disease (AD), Down syndrome (DS), and bipolar disorder (BD).\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePRODUCT DETAILS\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone:\u003c\/b\u003e W21139F\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAntibody Type:\u003c\/b\u003e Monoclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity:\u003c\/b\u003e Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat:\u003c\/b\u003e DBN1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost:\u003c\/b\u003e Rat \u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype:\u003c\/b\u003e IgG2b, κ\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications:\u003c\/b\u003e ICC - Quality tested ICFC - Verified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRegulatory Status:\u003c\/b\u003e RUO\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eData Sheets:\u003c\/strong\u003e \u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/TDS\/biolegend\/alexa-fluor-647-anti-dbn1-25866+(TDS).pdf\" target=\"_blank\"\u003eTDS\u003c\/a\u003e | \u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/SDS\/biolegend\/Pure_Conjugated_Antibodies_SDS_United_States_English_V2.pdf\" target=\"_blank\"\u003eSDS\u003c\/a\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eNote to Purchaser: \u003c\/strong\u003eThis product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.\u003c\/p\u003e","brand":"BioLegend","offers":[{"title":"25 μg","offer_id":43210703765540,"sku":"633253","price":180.0,"currency_code":"USD","in_stock":true},{"title":"100 μg","offer_id":43210703798308,"sku":"633254","price":455.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1654\/6801\/files\/alexa-fluor-647-anti-dbn1-25866_0.png?v=1769482059","url":"https:\/\/cytekbio.com\/products\/alexa-fluor-647-anti-dbn1-w21139f","provider":"Cytek Biosciences","version":"1.0","type":"link"}