{"product_id":"cfluor-byg667-anti-human-cd183-cxcr3-cew33d","title":"cFluor\u003csup\u003e\u0026reg;\u003c\/sup\u003e BYG667 Anti-Human CD183 (CXCR3) (CEW33D)","description":"\u003cp\u003eThe mouse monoclonal antibody clone CEW33D binds to human CD183, also known as CXCR3. CD183 is a G protein-coupled chemokine receptor that interacts with ligands CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC). CD183 is strongly associated with type 1 immunity. It is induced in naive T cells upon activation and remains upregulated in T helper type (Th)1 cells, CD8 effector cells, NK cells, and NKT cells. CD183-ligand interactions mediate infiltration of inflamed tissues in normal type 1 immune responses as well as in many inflammatory and autoimmune diseases. CD183 is also expressed on some B cells and plasmacytoid DC.\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePRODUCT DETAILS\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone\u003c\/b\u003e: CEW33D\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecificity\u003c\/b\u003e: CD183 (CXCR3)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat\u003c\/b\u003e: cFluor\u003csup\u003e®\u003c\/sup\u003e BYG667\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e: Mouse IgG1, k\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Dilution\u003c\/b\u003e: 5 µL\/Test\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Flow Cytometry\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: 2-8°C protected from light. \u003cb\u003eDo not freeze\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eData Sheets: \u003c\/b\u003e\u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/TDS\/cfluor\/R8-50513+Rev.+B_TDS_cFluor+BYG667+Anti-Human+CD183+(CXCR3)+(CEW33D).pdf\" target=\"_blank\"\u003eTDS\u003c\/a\u003e | \u003ca href=\"https:\/\/cytek-web.s3.us-east-1.amazonaws.com\/cytekbio.com\/documentation-center\/SDS\/R9-70004+Rev.+E_SDS+fluorescent+conjugated+Abs.pdf\" target=\"_blank\"\u003eSDS\u003c\/a\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eRECOMMENDED USAGE\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eEach lot of this antibody is quality control tested using flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 μL per 1 million cells in a staining volume of 100 μL. If whole blood is analyzed, then use 5 μL per 100 μL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application.\u003cbr\u003e\u003cbr\u003ePlease briefly centrifuge the reagent vial before use.\u003cbr\u003e\u003cbr\u003eUse appropriate personal protective equipment per the product safety data sheet when using this product.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\u003col\u003e\n\u003cli\u003eLoetscher M, et al. 1996. J. Exp. Med. 184:963-969.\u003c\/li\u003e\n\u003cli\u003eCole KE, et al. 1998. J. Exp. Med. 187:2009-2021.\u003c\/li\u003e\n\u003cli\u003eAksoy MO, et al. 2006. Am. J. Physiol. Lung Cell Mol. Physiol. 290:L909-L918.\u003c\/li\u003e\n\u003cli\u003eCurbishley SM, et al. 2005. Am. J. Pathol. 167:887-899.\u003c\/li\u003e\n\u003cli\u003eTurner JE, et al. 2007. Mini. Rev. Med. Chem. 7:1089-1096.\u003c\/li\u003e\n\u003cli\u003eWenzel J, et al. 2008. J. Invest. Dermatol. 128:67-78.\u003c\/li\u003e\n\u003cli\u003eHoerning A, et al. 2011. Eur. J. Immunol 41:2291-2302.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eFor research use only. Not intended for use in diagnostic procedures.\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003ecFluor\u003csup\u003e®\u003c\/sup\u003e BYG667 is a tandem dye made with R-PE. Caution – Tandem dyes may show changes in their emission spectra with prolonged exposure to light or fixatives.\u003c\/p\u003e","brand":"Cytek Biosciences","offers":[{"title":"100 Tests","offer_id":44228302209060,"sku":"R7-20513","price":475.0,"currency_code":"USD","in_stock":true},{"title":"25 Tests","offer_id":44228302241828,"sku":"R7-20514","price":185.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1654\/6801\/files\/R8-50513_left_x_R8-50513_right_combined.png?v=1780511043","url":"https:\/\/cytekbio.com\/ja\/products\/cfluor-byg667-anti-human-cd183-cxcr3-cew33d","provider":"Cytek Biosciences","version":"1.0","type":"link"}