{"product_id":"alexa-fluor-647-anti-tau-phospho-thr231-a23009a","title":"Alexa Fluor® 647 anti-Tau Phospho (Thr231)","description":"\u003cp\u003e\u003c\/p\u003e\u003cp\u003ePaired helical filaments (PHFs) are the major building blocks of neurofibrillary lesions in Alzheimer's disease brains and are composed of hyperphosphorylated Tau protein. Predominantly expressed in axons, alternatively spliced forms of Tau comprise a family of microtubule-associated proteins that normally promote and stabilize the assembly of microtubules. PHF-Tau differs from normal Tau by its abnormal hyperphosphorylation, which results in decreased binding of Tau to microtubules. The decreased affinity of PHF-Tau for microtubules, coupled with reduced levels of normal Tau, destabilizes microtubules leading to an impairment of axonal transport, neuronal death and the aggregation of PHFs. Therefore, hyperphosphorylation of Tau is believed to be a key event in the pathogenesis of Alzheimer's disease.\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003ePRODUCT DETAILS\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone:\u003c\/b\u003e A23009A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAntibody Type:\u003c\/b\u003e Monoclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity:\u003c\/b\u003e Human, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormat:\u003c\/b\u003e Tau Phospho Thr231\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost:\u003c\/b\u003e Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype:\u003c\/b\u003e IgG2b, κ\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications:\u003c\/b\u003e IHC-P - Quality tested\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRegulatory Status:\u003c\/b\u003e RUO\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eData Sheets:\u003c\/strong\u003e \u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/TDS\/biolegend\/alexa-fluor-647-anti-tau-phospho-thr231-26226+(TDS).pdf\" target=\"_blank\"\u003eTDS\u003c\/a\u003e | \u003ca href=\"https:\/\/cytek-web.s3.amazonaws.com\/cytekbio.com\/documentation-center\/SDS\/biolegend\/Pure_Conjugated_Antibodies_SDS_United_States_English_V2.pdf\" target=\"_blank\"\u003eSDS\u003c\/a\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cp\u003e\u003cstrong\u003eNote to Purchaser: \u003c\/strong\u003eThis product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.\u003c\/p\u003e","brand":"BioLegend","offers":[{"title":"25 μg","offer_id":43210701897764,"sku":"683853","price":190.0,"currency_code":"USD","in_stock":true},{"title":"100 μg","offer_id":43210701930532,"sku":"683854","price":470.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1654\/6801\/files\/alexa-fluor-647-anti-tau-phospho-thr231-26226_0.png?v=1769482046","url":"https:\/\/cytekbio.com\/ja\/products\/alexa-fluor-647-anti-tau-phospho-thr231-a23009a","provider":"Cytek Biosciences","version":"1.0","type":"link"}